Tom Terwilliger is a structural biologist and methods developer who has worked in the areas of macromolecular crystallography, cryo-electron microscopy and AI-driven structure determination. He is a member of the National Academy of Sciences, a member of the Phenix software team, and a Senior Scientist at the New Mexico Consortium.
Terwilliger studied physics at Harvard and molecular biology at UCLA with David Eisenberg and at Berkeley with Daniel E. Koshland, Jr. He was a Presidential Young Investigator at the University of Chicago and a Laboratory Fellow at Los Alamos National Laboratory.
His SOLVE software was the first fully automated method for macromolecular structure analysis using experimental phasing, and his RESOLVE software was the first likelihood-based method for improving crystallographic density maps. More recently, he has developed structure determination tools for analysis of cryo-EM maps and for integrating AlphaFold predictions into experimental structure determination.
In addition to methods development, he helped establish the field of Structural Genomics, led the International Structural Genomics Organization from its inception, and directed two large-scale structural genomics projects.
This site serves as a permanent home for his publication list, software history, and professional materials formerly hosted at Los Alamos National Laboratory.
Publications
Peer-reviewed papers from four decades of structural biology and methods development.
View full list →Phenix Software
Comprehensive tools for macromolecular structure determination using X-rays, neutrons, and cryo-EM.
phenix-online.org →SOLVE & RESOLVE
Automated tools for experimental phasing and density modification, now part of Phenix.
Software & documentation →